![]() They differ in appearance depending on the body site.They may arise on any part of the body. ![]() Melanocytic naevi vary widely in clinical, dermatoscopic and histological appearance. What are the clinical features of melanocytic naevi? Immunosuppressive treatment leads to an increase in the numbers of naevi.People living in Australia and New Zealand have many more naevi than their relatives residing in Northern Europe.New melanocytic naevi may erupt following the use of BRAF inhibitor drugs ( vemurafenib, dabrafenib).Somatic mutations in RAS genes are associated with congenital melanocytic naevi.People with many melanocytic naevi tend to have family members that also have many similar lesions.What causes melanocytic naevi?Īlthough the exact reason for the local proliferation of naevus cells is unknown, it is clear that the number of melanocytic naevi a person has depends on genetic factors, on sun exposure, and on immune status. Most white-skinned New Zealanders have 20–50 melanocytic naevi. Melanocytic naevi that are acquired later in childhood or adult life often follow sun exposure and may fade away or involute later.Melanocytic naevi that appear during childhood (aged 2 to 10 years) tend to be the most prominent and persistent throughout life.Fair-skinned people tend to have more melanocytic naevi than darker skinned people.This is usually sporadic, with rare instances of familial congenital naevi. About 1% of individuals are born with one or more congenital melanocytic naevi.Who gets melanocytic naevi?Īlmost everyone has at least one melanocytic naevus. There are various kinds of congenital and acquired melanocytic naevi (American spelling 'nevi'). A brown or black melanocytic naevus contains the pigment melanin, so may also be called a pigmented naevus.Ī melanocytic naevus can be present at birth (a congenital melanocytic naevus) or appear later (an acquired naevus). It is sometimes called a naevocytic naevus or just 'naevus' (but note that there are other types of naevi). A melanocytic naevus (American spelling ‘ nevus’), or mole, is a common benign skin lesion due to a local proliferation of pigment cells ( melanocytes).
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